Junfeng Xia, PhD

Professor, Institutes of Physical Science and Information Technology
Anhui University, Hefei, Anhui 230601, China
Tel: 86-551-63861990
E-mail: jfxia@ahu.edu.cn; junfeng.xia@foxmail.com

Personal Profile

Junfeng Xia was born in Anhui Province, China. He received his BS degree in Biotechnology in 2005 from Anhui University and PhD degree in Bioinformatics from University of Science and Technology of China in 2010. From 2010 to 2013 he was postdoctoral research fellow at Department of Biomedical Informatics, Vanderbilt University. Since 2013, he has been a professor of bioinformatics at Institutes of Physical Science and Information Technology, Anhui University.

Research Interests

We are interested in developing and applying computational tools for the study of functional effects for mutations in human genomes. One current focus is to develop reliable and efficient ways of analyzing synonymous mutations and indels (insertion/deletions). Another focus is to develop computational methods to predict the effects of mutations on protein-protein interactions and protein-nucleic acids interactions. To make our predictions we rely on a number of sequence-based features (including physicochemical features, predicted structural features, evolutionary information, and available functional annotations) and utilize a variety of computational methodologies (including machine learning methods). We are also actively developing bioinformatics databases and webservers.

Professional Services

  • Associate Editor, BMC Genomics, 2018-present
  • Associate Editor, BMC Medical Genomics, 2019-present
  • Program Committee Member, International Conference on Intelligent Computing, 2011-2019
  • Program Committee Member, International Conference on Intelligent Biology and Medicine, 2015-2019
  • Program Committee Member, IEEE International Conference on Bioinformatics and Biomedicine, 2018-2019

Selected Publications (*corresponding author)

1. Yannan Bin, Xiaojuan Wang, Le Zhao, Pengbo Wen and Junfeng Xia*, An analysis of mutational signatures of synonymous mutations across 15 cancer types. BMC Medical Genetics 2019, 20(Suppl 2):190
2. Na Cheng, Menglu Li, Le Zhao, Bo Zhang, Yuhua Yang, Chun-Hou Zheng and Junfeng Xia*, Comparison and integration of computational methods for deleterious synonymous mutation prediction. Briefings in Bioinformatics, 2019, doi:10.1093/bib/bbz047 (accepted)
3. Sijia Zhang, Le Zhao, Chun-Hou Zheng and Junfeng Xia*, A feature-based approach to predict hot spots in protein-DNA binding interfaces. Briefings in Bioinformatics, 2019, doi:10.1093/bib/bbz037 (accepted)
4. Fang Shi, Yao Yao, Yannan Bin, Chun-Hou Zheng and Junfeng Xia*, Computational identification of deleterious synonymous variants in human genomes using a feature-based approach. BMC Medical Genomics 2019, 12 (S1):12
5. Zhenyu Yue, Le Zhao, Na Cheng and Junfeng Xia*, dbCID: a manually curated resource for exploring the driver indels in human cancer. Briefings in Bioinformatics, 2018, doi:10.1093/bib/bby059
6. Zhenyu Yue, Le Zhao and Junfeng Xia*, dbCPM: a manually curated database for exploring the cancer passenger mutations. Briefings in Bioinformatics, 2018, doi:10.1093/bib/bby105
7. Pengbo Wen, Junfeng Xia*, Xianbin Cao, Bin Chen, Yinping Tao, Lijun Wu, An Xu and Guoping Zhao*, dbCRSR: a manually curated database for regulation of cancer radiosensitivity. Database, 2018, 2018: bay049
8. Shu-Guang Ge, Junfeng Xia, Wen Sha and Chun-Hou Zheng, Cancer Subtype Discovery Based on Integrative Model of Multigenomic Data. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2017, 14(5): 1115-1121
9. Pi-Jing Wei, Di Zhang, Hai-Tao Li, Junfeng Xia and Chun-Hou Zheng, DriverFinder: A Gene Length-Based Network Method to Identify Cancer Driver Genes. Complexity, 2017, 2017: 4826206
10. Pengbo Wen, Peng Xiao, and Junfeng Xia*, dbDSM: a manually curated database for deleterious synonymous mutations. Bioinformatics, 2016, 32(12): 1914-1916
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