Melanoma is one of the most aggressive human cancers. Similar to many other cancers, melanoma is initiated by activation of oncogenes or inactivation of tumor suppressor genes. However, there is no database focusing on genes involved in melanoma causation yet available. Therefore, we have collected melanoma related genes to construct an integrated database termed Melanoma Gene DataBase (MGDB) that would help in understanding the relationship between genes and melanoma.
Each entry contains information regarding the general information, expression, methylation, mutation, interaction, pathways and drug information. These information were extracted from other resource like NCBI, TCGA, COSMIC, PINA, KEGG and DGIdb enriching MGDB-specific information with external data. We also provide online BLAST tool which makes it possible to query against the melanoma gene nucleotide or protein sequences in our MGDB.
Please cite the paper, if you are using the information in the database: Di Zhang, Rongrong Zhu, Hanqian Zhang, Chun-Hou Zheng, and Junfeng Xia, MGDB: a comprehensive database of genes involved in melanoma, Database, 2015, 2015: bav097.