Welcome to dbCPG

Cancer predisposition genes (CPGs) generally refer to a class of genes in which germline mutations confer high or moderate risks of cancers (Nature 505(7483):302-308, 2014). Identification of these genes and understanding their functions are critical for further investigation of tumorigenesis. However, there is no database focusing on cancer predisposition genes yet available. Therefore, we developed a comprehensive literature-based cancer predisposition gene database (dbCPG). The purpose of the database is to allow cancer researchers to quickly determine whether or not a gene, or list of genes, has been identified as a cancer predisposition gene with literature evidence. A brief tutorial is available here.

Number of cancer predisposition genes in dbCPG:

918 human genes (800 coding, 38 non-coding and 80 unknown type genes), 732 mouse genes, and 707 rat genes.

Please cite this paper if you use dbCPG in your study:

Ran Wei, Yao Yao, Wu Yang, Chun-Hou Zheng, Min Zhao, and Junfeng Xia, dbCPG: A web resource for cancer predisposition genes, Oncotarget, 2016, 7(25): 37803-37811.